Jeroen Kalkman's huispagina
Research interests
My research interest are in the development and improvement of optical imaging technology. Currently I am focused on the optical imaging technique called optical
coherence tomography (OCT). OCT is the optical analogue of ultrasound, where the amplitude of the reflected wave is measured against time to create depth images. OCT uses low-coherence
interferometry to measure the time of flight of light scattered back from tissue. OCT can image up to a few millimeters deep in tissue with a resolution in the order of 10
micron. In addition, OCT can measure (blood) flow, tissue birefringence, refractive index, and diffusion in tissue.
Currently I'm working on two projects:
1) Miniaturization of OCT
Together with acadmic (University Twente) and commercial partners (LioniX, 2M Sensors, Oclaro) we are focusing on the integration of electronics and photonics for OCT. Current commercial OCT systems contain a lot of optical and electronic components, which makes these systems complex, bulky, and expensive. Photonic and electronic integration can reduce the costs and improve the performance of OCT systems.
We use photonic integrated circuits to replace the many optical OCT components. Photonic integrated circuits contain optical structures that guide and shape the light, all on a single and small chip. Theese photonic integrated cicuits are connected to electronic circuits to create a compact and low cost OCT device. In the past, we have focused on photonic structures that replace a single element of the OCT device. Currently, we are in the stage of further photonic and electronic integration and will make a small form factor OCT device.
This work is funded by the Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science and supported by the IOP Photonic Devices program managed Agentschap NL.
2) Improvement of OCT technology
The study of light tissue interaction in OCT and the construction of the OCT signal is of great importance in extracting more information from tissue. Studying the OCT signal construction we have shown that parameters such as diffusion coefficient and scattering anisotropy can be determined quantitatively. Moreover, we have studied the effect of multiple scattering on the OCT attenuation coefficient and Doppler flow profile. We are currently looking at extracting flow information for very small capillaries and are investigating new imaging schemes.
This work is funded by the Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science and supported by the IOP Photonic Devices program managed Agentschap NL.
Currently I'm working on two projects:
1) Miniaturization of OCT
Together with acadmic (University Twente) and commercial partners (LioniX, 2M Sensors, Oclaro) we are focusing on the integration of electronics and photonics for OCT. Current commercial OCT systems contain a lot of optical and electronic components, which makes these systems complex, bulky, and expensive. Photonic and electronic integration can reduce the costs and improve the performance of OCT systems.
We use photonic integrated circuits to replace the many optical OCT components. Photonic integrated circuits contain optical structures that guide and shape the light, all on a single and small chip. Theese photonic integrated cicuits are connected to electronic circuits to create a compact and low cost OCT device. In the past, we have focused on photonic structures that replace a single element of the OCT device. Currently, we are in the stage of further photonic and electronic integration and will make a small form factor OCT device.
This work is funded by the Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science and supported by the IOP Photonic Devices program managed Agentschap NL.
2) Improvement of OCT technology
The study of light tissue interaction in OCT and the construction of the OCT signal is of great importance in extracting more information from tissue. Studying the OCT signal construction we have shown that parameters such as diffusion coefficient and scattering anisotropy can be determined quantitatively. Moreover, we have studied the effect of multiple scattering on the OCT attenuation coefficient and Doppler flow profile. We are currently looking at extracting flow information for very small capillaries and are investigating new imaging schemes.
This work is funded by the Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science and supported by the IOP Photonic Devices program managed Agentschap NL.
